AMPKα2 is a skeletal muscle stem cell intrinsic regulator of myonuclear accretion
Stem cells research
Molecular biology experimental approach
Science
Q
[SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]
Specialized functions of cells
Molecular mechanism of behavior
Article
cell Biology
DOI:
10.1016/j.isci.2023.108343
Publication Date:
2023-10-27T00:37:04Z
AUTHORS (11)
ABSTRACT
Due to the post-mitotic nature of skeletal muscle fibers, adult maintenance relies on dedicated stem cells (MuSCs). In most physiological contexts, MuSCs support myofiber homeostasis by contributing myonuclear accretion, which requires a coordination cell-type specific events between and MuSCs. Here, we addressed role kinase AMPKα2 in these supporting accretion. We demonstrate that deletion impairs regeneration. Through vitro assessments MuSC myogenic fate EdU-based cell tracing, reveal MuSC-specific regulation is mediated phosphorylation non-metabolic substrate BAIAP2. Similar tracing vivo shows knockout mice have lower rate accretion during regeneration, decreases response contraction. Together, this demonstrates MuSC-intrinsic regulator
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