Hospital-treated prevalent infections, the plasma proteome and incident dementia among UK older adults

• DOI: 10.1016/j.isci.2023.108526
• Publication Date: 2023-11-23T23:32:09Z
• Authors: May A. Beydoun; Hind A. Beydoun; Nicole Noren Hooten; Osorio Meirelles; Zhiguang Li; Ziad W. El-Hajj; Jordan Weiss; Christian A. Main...; Lenore J. Launer; Michele K. Evans; Alan B. Zonderman
• Keywords: Proteome; GDF15

The plasma proteome can mediate the association of hospital-treated infections with dementia incidence. We screened up to 37,269 UK Biobank participants aged 50–74 years for presence a prevalent infection, subsequently tested as predictor ≤1,463 proteins and Four-way decomposition models decomposed infection-dementia total effect into pure mediation, interaction, neither or both through proteome. Hospital-treated increased two-fold. strongest mediation was growth differentiation factor 15 (GDF15) protein. Top 17 proteomic mediators explained collectively 5% effect, while pathway analysis all (k = 221 proteins) revealed top pathways including immune system, signal transduction, metabolism, disease metabolism proteins, GDF15 cluster reflecting most strongly "transmembrane receptor protein tyrosine kinase signaling pathway". partially mediated other markers.