Aedes aegypti saliva modulates inflammasome activation and facilitates flavivirus infection in vitro

• DOI: 10.1016/j.isci.2023.108620
• Publication Date: 2023-12-03T00:10:09Z
• Authors: Gaurav Shrivastava; Paola Carolina Va...; Karina Botello; Eric Calvo
• Keywords: Zika Virus; Flavivirus

Mosquito borne flaviviruses such as dengue and Zika represent a major public health problem due to globalization propagation of susceptible vectors worldwide. Vertebrate host responses infections include the processing release pro-inflammatory cytokines through activation inflammasomes, resulting in disease severity fatality. saliva can facilitate pathogen infection by downregulating host's immune response. However, role mosquito modulating innate remains largely unknown. Here, we show that salivary gland extract (SGE) inhibits virus-induced inflammasome reducing NLRP3 expression, Caspase-1 activation, 1L-1β secretion cultured human mice macrophages. As result, observe SGE virus detection early phase infection. This study provides important insights into how modulates immunity during viral