Revealing splenectomy-driven microRNA hsa-7b-5p’s role in pancreatic cancer progression

• DOI: 10.1016/j.isci.2024.109045
• Publication Date: 2024-01-26T21:07:53Z
• Authors: Liangliang Wu; Yongjie Xie; Bo Ni; Peng Jin; Bin Li; Mingzhi Cai; Baogui Wang; Chengyan Wu; Yuexiang Liang; Xiaona Wang
• Keywords: Immunosuppression; Cancer immunology

Splenectomy often accompanies distal pancreatectomy for pancreatic cancer. However, debates persist on splenic function loss impact. Prior studies in mice revealed splenectomy promotes cancer growth by altering CD4/Foxp3 and CD8/Foxp3 ratios. The effect other immune cells remains unclear. Clinical observations indicate induces immunosuppression, heightening recurrence metastasis risk. Here, we established an orthotopic model with observed a significant increase tumor burden. Flow cytometry elevated MDSCs, CD8+PD-1high+ T cells, reduced CD4