CD169+ classical monocyte as an important participant in Graves’ ophthalmopathy through CXCL12-CXCR4 axis

• DOI: 10.1016/j.isci.2024.109213
• Publication Date: 2024-02-10T03:25:01Z
• Authors: Dongliang Wang; Jie Ling; RongQiang Tan; Huishi Wang; Yixin Qu; Xingyi Li; Jinshan Lin; Qikai Zhang; Qiuling Hu; Zhong Liu; Zhaojing Lu; Yuheng Lin; Li Sun; Dingqiao Wang; Ming Zhou; Zhuoxing Shi; Wuyou Gao; Huijing Ye; Xianchai Lin
• Keywords: Graves' ophthalmopathy; Monocyte; CD16

Patients with Graves' disease (GD) can develop ophthalmopathy (GO), but the underlying pathological mechanisms driving this development remain unclear. In our study, which included patients GD and GO, we utilized single-cell RNA sequencing (scRNA-seq) multiplatform analyses to investigate CD169