Functional diversification of innate and inflammatory immune responses mediated by antibody fragment crystallizable activities against SARS-CoV-2

• DOI: 10.1016/j.isci.2024.109703
• Publication Date: 2024-04-11T01:21:56Z
• Authors: Martina Severa; Marilena Paola Etna; Emanuele Andreano; Daniela Ricci; Giada Cairo; Stefano Fiore; Andrea Canitano; Andrea Cara; Paola Stefanelli; Rino Rappuoli; Anna Teresa Palamara; Eliana Marina Coccia
• Keywords: 0301 basic medicine; 03 medical and health sciences; Virology; Science; Immunology; Q; Immune response; immune response; immunology; virology.; Article

Monoclonal antibodies (mAb) targeting the SARS-CoV-2 Spike (S) glycoprotein have been exploited for treatment of severe COVID-19. In this study, we evaluated immune-regulatory features two neutralizing anti-S mAbs (nAbs), named J08 and F05, with wild-type (WT) conformation or silenced Fc functions. presence D614G SARS-CoV-2, WT nAbs enhance intracellular viral uptake in immune cells amplify antiviral type I Interferon inflammatory cytokine chemokine production without replication, promoting differentiation CD16