Integrative neurovascular coupling and neurotransmitter analyses in anisometropic and visual deprivation amblyopia children

• DOI: 10.1016/j.isci.2024.109988
• Publication Date: 2024-05-16T08:04:17Z
• Authors: Xiaopan Zhang; Liang Liu; Yadong Li; Xiao Li; Kejia Wang; Shaoqiang Han; Mengzhu Wang; Yong Zhang; Guangying Zheng; Jingliang Cheng; Baohong Wen
• Keywords: Neurotransmitter Systems; Neurovascular bundle; Anisometropia; Monocular deprivation; Sensory deprivation

The association between visual abnormalities and impairments in cerebral blood flow brain region potentially results neural dysfunction of amblyopia. Nevertheless, the differences complex mechanisms network coupling its relationship with neurotransmitters remain unclear. Here, neurovascular mechanism neurotransmitter activity children anisometropic amblyopia (AA) deprivation (VDA) was explored. 17 regions significantly abnormal than normal controls. classification abilities units differed two types Correlations different effects were different. findings this study demonstrate a correlation AA VDA, implying their impaired function potential molecular underpinnings. neuroimaging evidence revealed herein offers for development therapies