Detection of Ischemic ST-Segment Changes Using a Novel Handheld ECG Device in a Porcine Model

• DOI: 10.1016/j.jacadv.2023.100410
• Publication Date: 2023-07-19T17:58:57Z
• Authors: Nynke M. de Vries; Alejandra Zepeda-...; Rutger R. van de ...; Vera Loen; Marc A. Vos; Machteld J. Boonstra; Thierry X. Wildbergh; Joris E.N. Jaspers; Rien van der Zee; Cornelis H. Slump; Pieter A. Doevendans; René van Es
• Keywords: STEMI; 03 medical and health sciences; 0302 clinical medicine; cardiac ischemia; translational research; electrocardiography; portable; Dentistry (miscellaneous); Cardiology and Cardiovascular Medicine; Original Research

Portable, smartphone-sized electrocardiography (ECG) has the potential to reduce time treatment for patients suffering acute cardiac ischemia, thereby lowering morbidity and mortality. In UMC Utrecht, a portable, smartphone-sized, multi-lead precordial ECG recording device (miniECG 1.0, Utrecht) was developed. The purpose of this study investigate ability miniECG capture ischemic changes in porcine coronary occlusion model. 8 animals, antero-septal myocardial infarction induced by 75-minute left anterior descending artery, after first or second diagonal. MiniECG 12-lead recordings were acquired simultaneously before, during artery ST-segment deviation evaluated. During complete reperfusion period, showed large comparison ECG. observed within 1 minute most animals. positive ischemia (ie, ≥1 mm) 99.7% (Q1-Q3: 99.6%-99.9%) time, while only 79.8% 81.1%-98.7%) (P = 0.018). reached maxima 10.5 mm [95% CI: 6.5-14.5 mm] vs 5.0 2.0-8.0 ECG, respectively. early magnitude 75 minutes transmural infarction. period. These findings demonstrate detection ischemia. Although clinical research is required, data suggests that promising tool