A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function

• DOI: 10.1016/j.jacbts.2016.06.005
• Publication Date: 2016-08-30T09:15:21Z
• Authors: Isaac Perea-Gil; Cristina Prat-Vidal; Carolina Gálvez-M...; Santiago Roura; Aida Llucià-Valld...; Carolina Soler-Bo...; Oriol Iborra-Egea; Idoia Díaz-Güemes; Verónica Crisóstomo; Francisco M. Sánc...; Antoni Bayes-Genis
• Keywords: Decellularization; Myocardial fibrosis

Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of despite current treatment. Here, authors engineered cell-enriched myocardial graft, composed decellularized matrix refilled with adipose tissue-derived progenitor cells (EMG-ATDPC). Once applied over infarcted area in swine MI model, EMG-ATDPC improved cardiac function, reduced infarct size, attenuated fibrosis progression, promoted neovascularization ischemic myocardium. The beneficial effects exerted by absence identified adverse side should facilitate its clinical translation as novel therapy humans.