Plasma Proteomics of COVID-19–Associated Cardiovascular Complications

• DOI: 10.1016/j.jacbts.2022.01.013
• Publication Date: 2022-05-04T19:52:57Z
• Authors: Jason D. Roh; Robert R. Kitchen; J. Sawalla Guseh; Jenna N. McNeill; Malika Aid; Amanda J. Martinot; Andy Yu; Colin Platt; James Rhee; Brittany Weber; Lena E. Trager; Margaret H. Hastings; Sarah Ducat; Peng Xia; Claire Castro; Abhilasha Singh; Bjarni Atlason; Timothy W. Churchill; Marcelo F. Di Carli; Patrick T. Ellinor; Dan H. Barouch; Jennifer E. Ho; Anthony Rosenzweig
• Keywords: Senescence; Pathophysiology

To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study COVID-19 patients. Our results identify senescence-associated secretory phenotype, marker of biological aging, as dominant process associated with disease severity and cardiac involvement. FSTL3, an indicator senescence-promoting Activin/TGFβ signaling, ADAMTS13, von Willebrand Factor–cleaving protease whose loss-of-function causes microvascular thrombosis, were among proteins most strongly myocardial stress injury. Findings validated larger patient cohort hamster model, providing new pathophysiology therapeutic implications.