IGF-1 Therapy Improves Muscle Size and Function in Experimental Peripheral Arterial Disease

• DOI: 10.1016/j.jacbts.2022.12.006
• Publication Date: 2023-03-08T18:02:40Z
• Authors: Gengfu Dong; Chatick Moparthy; Trace Thome; Kyoungrae Kim; Feng Yue; Terence E. Ryan
• Keywords: Medical Therapy

Lower-extremity peripheral arterial disease (PAD) has increased in prevalence, yet therapeutic development remained stagnant. Skeletal muscle health and function been strongly linked to quality of life medical outcomes patients with PAD. Using a rodent model PAD, this study demonstrates that treatment the ischemic limb insulin-like growth factor (IGF)-1 significantly increases size strength without improving hemodynamics. Interestingly, effect IGF1 therapy was larger female mice than male mice, highlighting need carefully examine sex-dependent effects experimental PAD therapies.