Carotid Baroreceptor Stimulation Improves Pulmonary Arterial Remodeling and Right Ventricular Dysfunction in Pulmonary Arterial Hypertension

• DOI: 10.1016/j.jacbts.2024.01.012
• Publication Date: 2024-04-22T19:03:45Z
• Authors: Jing Wang; Jie Chen; Ling Shu; Ruoliu Zhang; Mingyan Dai; Xuesheng Fang; Zhiling Hu; Lingling Xiao; Zhaoqing Xi; Junxia Zhang; Mingwei Bao

Autonomic nervous system imbalance is intricately associated with the severity and prognosis of pulmonary arterial hypertension (PAH). Carotid baroreceptor stimulation (CBS) a nonpharmaceutical intervention for autonomic neuromodulation. The effects CBS on monocrotaline-induced PAH were investigated in this study, its underlying mechanisms elucidated. results indicated that improved hemodynamic status alleviated right ventricular dysfunction, improving remodeling remodeling, thus enhancing survival rate rats. beneficial treatment might be mediated through inhibition sympathetic overactivation inflammatory immune signaling pathways.