2-Year Outcomes of Angiographic Quantitative Flow Ratio-Guided Coronary Interventions

• DOI: 10.1016/j.jacc.2022.09.007
• Publication Date: 2022-09-19T17:09:42Z
• Authors: Lei Song; Bo Xu; Shengxian Tu; Changdong Guan; Zening Jin; Bo Yu; Guosheng Fu; Yujie Zhou; Jian’an Wang; Yundai Chen; Jun Pu; Lianglong Chen; Xinkai Qu; Junqing Yang; Xuebo Liu; Lijun Guo; Chengxing Shen; Yaojun Zhang; Qi Zhang; Hongwei Pan; Rui Zhang; Jian Liu; Yanyan Zhao; Yang Wang; Kefei Dou; Ajay J. Kirtane; Yongjian Wu; William Wijns; Weixian Yang; Martin B. Leon; Shubin Qiao; Gregg W. Stone
• Keywords: Mace; Fractional Flow Reserve; Clinical endpoint

In the multicenter, randomized, sham-controlled FAVOR (Comparison of Quantitative Flow Ratio Guided and Angiography Guided Percutaneous Intervention in Patients with Coronary Artery Disease) III China trial, quantitative flow ratio (QFR)-based lesion selection improved 1-year clinical outcomes compared with conventional angiographic guidance for percutaneous coronary intervention (PCI).The purpose of this study was to determine whether the benefits of QFR guidance persist at 2 years, particularly for patients in whom QFR changed the revascularization strategy.Eligible patients were randomized to a QFR-guided strategy (PCI performed only if QFR ≤0.80) or a standard angiography-guided strategy. Major adverse cardiac events (MACE), a composite of all-cause death, myocardial infarction (MI), or ischemia-driven revascularization occurring within 2 years were analyzed in the intention-to-treat population.Among 3,825 randomized participants, 2-year MACE occurred in 161 of 1,913 (8.5%) patients in the QFR-guided group and in 237 of 1,912 (12.5%) patients in the angiography-guided group (HR: 0.66; 95% CI: 0.54-0.81; P < 0.0001), driven by fewer MIs (4.0% vs 6.8%; HR: 0.58; 95% CI: 0.44-0.77; P = 0.0002) and ischemia-driven revascularizations (4.2% vs 5.8%; HR: 0.71; 95% CI: 0.53-0.95; P = 0.02) in the QFR-guided group. Landmark analysis showed consistent results within the first year and between 1-2 years (Pint = 0.99). Although the 2-year MACE rate was lower in the QFR-guided group in both patients with and without revascularization strategy changes, the extent of outcome improvement was greater (Pint = 0.009) among those patients in whom the preplanned PCI strategy was modified by QFR.QFR-guided lesion selection improved 2-year clinical outcomes compared with standard angiography guidance. The benefits were most pronounced among patients in whom QFR assessment altered the planned revascularization strategy. (FAVOR III China Study [The Comparison of Quantitative Flow Ratio Guided and Angiography Guided Percutaneous Intervention in Patients with Coronary Artery Disease] NCT03656848).