Effect of vitamin D supplementation on total and allergen-specific IgE in children with asthma and low vitamin D levels

• DOI: 10.1016/j.jaci.2021.05.037
• Publication Date: 2021-06-09T07:43:24Z
• Authors: Franziska J. Rosser; Yueh-Ying Han; Erick Forno; Leonard B. Bacharier; Wanda Phipatanakul; Theresa W. Guilbert; Michael D. Cabana; Kristie Ross; Joshua Blatter; Sandy Durrani; James Luther; Stephen R. Wisnie...; Juan C. Celedón
• Keywords: Male; Vitamins; Allergens; Immunoglobulin E; Asthma; Arthropod Proteins; 3. Good health; Cysteine Endopeptidases; 03 medical and health sciences; 0302 clinical medicine; Double-Blind Method; Dietary Supplements; Animals; Humans; Female; Antigens, Dermatophagoides; Vitamin D; Child

Observational studies have yielded inconsistent findings for the relation between vitamin D level and total IgE or allergic sensitization.To determine whether vitamin D supplementation reduces levels of total IgE and IgE to each of 2 common indoor allergens in children with asthma and low vitamin D levels.Total IgE, IgE to Dermatophagoides pteronyssinus, and IgE to Blattella germanica were measured at the randomization and exit visits for 174 participants in the Vitamin D Kids Asthma Study, a multicenter, double-blind, randomized placebo-controlled trial of vitamin D3 supplementation (4000 IU/d) to prevent severe exacerbations in children with persistent asthma and vitamin D levels less than 30 ng/mL. Multivariable linear regression was used for the analysis of the effect of vitamin D supplementation on change in each IgE measure.Participants were followed for an average of 316 days. At the exit visit, more subjects in the vitamin D arm achieved a vitamin D level equal to or more than 30 ng/mL compared with those in the placebo arm (87% vs 30%; P < .001). In a multivariable analysis, vitamin D3 supplementation had no significant effect on change in total IgE, IgE to Dermatophagoides pteronyssinus, or IgE to Blattella germanica between the exit and randomization visits (eg, for log10 total IgE, β = 0.007; 95% CI, -0.061 to 0.074; P = .85).Vitamin D supplementation, compared with placebo, has no significant effect on serum levels of total IgE, IgE to dust mite, or IgE to cockroach in children with asthma and low vitamin D levels.