Key risk factors of asthma-like symptoms are mediated through infection burden in early childhood

• DOI: 10.1016/j.jaci.2023.11.019
• Publication Date: 2023-11-22T08:43:48Z
• Authors: Julie Nyholm Kyvs...; Nicklas Brustad; Laura Marie Hesse...; Nilo Vahman; Jonathan Thorsen; Ann-Marie Malby S...; Klaus Bønnelykke; Jakob Stokholm; Bo Lund Chawes
• Keywords: Male; wheezing; Infant, Newborn; Infant; Pneumonia; dyspnea; infant; preschool child; infection; Asthma; 3. Good health; Anti-Bacterial Agents; cough; Pregnancy; Risk Factors; Respiratory signs and symptoms; Child, Preschool; risk factors; Humans; Female; Prospective Studies; mediation analysis; Respiratory Sounds

BackgroundRisk factors of asthma-like symptoms in childhood may act through an increased infection burden because infections often trigger these symptoms.ObjectiveWe sought to investigate whether the effect established risk episodes early is mediated and subtypes common infections.MethodsThe study included 662 children from Copenhagen Prospective Studies on Asthma Childhood 2010 mother-child cohort, which were registered prospectively daily diaries age 0 3 years. The association between was analyzed by quasi-Poisson regressions, mediation analyses performed for significant factors.ResultsIn first years life, experienced a median 16 (interquartile range, 12-23) infectious episodes. We found that significantly (PACME < .05) maternal asthma (36.6% mediated), antibiotics during pregnancy (47.3%), siblings at birth (57.7%), exacerbation polygenic score (30.6%), bacterial airway immune (80.2%) with number episodes, whereas higher male sex, low weight, gestational age, antibiotic use after not burden. Subtypes driving primarily colds, pneumonia, gastroenteritis, fever, but acute otitis media or tonsillitis.ConclusionsSeveral life. Prevention therefore be beneficial reduce childhood. Risk symptoms. infections. factors. In tonsillitis. Several