The ability of biomarkers to assess the severity of atopic dermatitis

• DOI: 10.1016/j.jacig.2023.100175
• Publication Date: 2023-09-27T01:44:16Z
• Authors: Takeshi Nakahara; Daisuke Onozuka; Satoshi Nunomura; Hidehisa Saeki; Motoi Takenaka; Mai Matsumoto; Yoko Kataoka; Rai Fujimoto; Sakae Kaneko; Eishin Morita; Akio Tanaka; Ryo Saito; Tatsuro Okano; Tomomitsu Miyagaki; Natsuko Aoki; Kimiko Nakajima; Susumu Ichiyama; Makiko Kido-Nakahara; Kyoko Tonomura; Yukinobu Nakagawa; Risa Tamagawa-Min...; Koji Masuda; Takuya Takeichi; Masashi Akiyama; Yozo Ishiuji; Michie Katsuta; Yuki Kinoshita; Chiharu Tateishi; Aya Yamamoto; Akimichi Morita; Haruna Matsuda-Hi...; Yutaka Hatano; Hiroshi Kawasaki; Ayano Fukushima-N...; Mamitaro Ohtsuki; Koji Kamiya; Yudai Kabata; Riichiro Abe; Hiroshi Mitsui; Tatsuyoshi Kawamura; Gaku Tsuji; Norito Katoh; Masutaka Furue; Kenji Izuhara
• Keywords: Biomarkers to Predict Clinical Improvement of AD in Patients Treated With Dupilumab; Brief Report; biomarker; eotaxin-3; EASI; B-PAD; Immunologic diseases. Allergy; RC581-607; 3. Good health; Atopic dermatitis

To develop precision medicine for atopic dermatitis (AD), it is critical to establish relevant biomarkers. However, the characteristics of various biomarkers have not been fully understood. We previously carried out Biomarkers Predict Clinical Improvement AD in Patients Treated with Dupilumab (B-PAD) study, a comprehensive nationwide study Japan, explore AD.The aim this find associated objective and subjective clinical findings patients moderate-to-severe based on B-PAD identify sensitive enough assess severity AD.We performed as consortium composed 19 medical facilities enrolling 110 AD. evaluated Eczema Area Severity Index (EASI) assessment well Patient-Oriented Measure (POEM) numeric rating scale pruritus (pruritis-NRS) assessment, measuring at baseline.We found that 12, 6, 7 showed significant positive associations EASI, POEM, pruritis-NRS, respectively. Most either POEM or pruritis-NRS were included among EASI. Of examined, CCL26/eotaxin-3 SCCA2 most capable assessing shown by 2 kinds receiver operating characteristic analyses, respectively, whereas lactate dehydrogenase was best both again using analyses.We study. Moreover, we identified and/or having greatest ability EASI; did same pruritis-NRS. These will be useful treating