Altered brain network modules induce helplessness in major depressive disorder

• DOI: 10.1016/j.jad.2014.05.061
• Publication Date: 2014-07-02T02:26:25Z
• Authors: Daihui Peng; Feng Shi; Ting Shen; Ziwen Peng; Chen Zhang; Xiaohua Liu; Meihui Qiu; Jun Liu; Kaida Jiang; Yiru Fang; Dinggang Shen
• Keywords: Adult; Male; Psychiatric Status Rating Scales; Depressive Disorder, Major; Emotions; Brain; Middle Aged; Magnetic Resonance Imaging; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Helplessness, Learned; Research Design; Case-Control Studies; Humans; Female

The abnormal brain functional connectivity (FC) has been assumed to be a pathophysiological aspect of major depressive disorder (MDD). However, it is poorly understood, regarding the underlying patterns of global FC network and their relationships with the clinical characteristics of MDD.