Assessing sleep architecture and cognition in older adults with depressive symptoms attending a memory clinic

• DOI: 10.1016/j.jad.2023.12.032
• Publication Date: 2023-12-18T19:00:34Z
• Authors: Andrea Ricciardiello; Andrew C. McKinnon; Loren Mowszowski; Haley M. LaMonica; Zoe Menczel Schrire; Carla Haroutonian; Aaron Lam; Ian B. Hickie; Angela D'Rozario; Sharon L. Naismith
• Keywords: Depression; Sleep

While depression is intrinsically and bidirectionally linked with both sleep disturbance cognition, the inter-relationships between sleep, brain integrity in older people depression, especially those late-onset are undefined. One hundred seventy-two adults (mean age 64.3 ± 6.9 years, Depression: n = 66, Control: 106) attending a memory clinic underwent neuropsychological battery of declarative memory, executive function tasks, cerebral magnetic resonance imaging overnight polysomnography quantitative electroencephalography. The time spent slow-wave (SWS) rapid eye movement (REM) activity, spindles, hippocampal volume prefrontal cortex thickness did not differ control onset groups. However, latency (p 0.005) REM 0.02) were later Depression group compared to controls. Less SWS was associated poorer (r 0.31, p 0.023) group, less related better −0.20, 0.043; Fishers r-to-z −3.19). Longitudinal studies needed determine if changes depressive symptoms predict cognitive decline illness trajectory. Older participants had delayed initiation, suggestive phase. association suggests may be useful target for intervention symptoms. Reduced volumes mediate this relationship, indicating broader distributed neural network underpin these associations.