Plasma autoantibodies in patients with Affective and Schizophrenic Spectrum Disorders

• DOI: 10.1016/j.jadr.2023.100563
• Publication Date: 2023-03-31T03:13:28Z
• Authors: Christian Scheiber; Alexander Dulcovic; Karl Bechter; E. Marion Schneider
• Keywords: Immune Dysregulation

A number of results emphasize autoimmune characteristics in psychiatric diseases, including Affective (AF) and Schizophrenic (SZ) Spectrum Disorders. In this study, serum/plasma samples n=34 AF (ICD-10 F30-F33) n=47 SZ F20-F25) patients, as well n=10 healthy controls (HDs), were tested for autoantibodies directed against cytokines different Type I, II III interferons using Luminex® technology. Significant amounts found. Specifically, IFN- λ (AF n=4, n=4), ω n=2, n=3), TNF-α n=1) selectively increased. The support dysregulation a contributing factor diseases. Interestingly, the detected patterns not between patients. humoral immunity common virus infections such EBV, CMV, HSV-1 HHV-6 is currently tested.