The ADAS‐Cog revisited: Novel composite scales based on ADAS‐Cog to improve efficiency in MCI and early AD trials

• DOI: 10.1016/j.jalz.2012.05.2187
• Publication Date: 2012-11-02T13:30:22Z
• Authors: Nandini Raghavan; Mahesh N. Samtani; Michael Farnum; Eric Yang; Gerald Novak; Michael Grundman; Vaibhav Narayan; Allitia DiBernardo
• Keywords: Cognitive test; Cog; Clinical endpoint

The Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) has been used widely as a cognitive end point in (AD) clinical trials. Efforts to treat AD pathology at earlier stages have also ADAS-Cog, but failure these trials can be difficult interpret because the scale well-known ceiling effects that limit its use mild impairment (MCI) and early AD. A wealth of data exists ADAS-Cog from both historical contemporary longitudinal natural history studies provide insights about parts may better suited for MCI