African‐American TOMM40'523‐APOEhaplotypes are admixture of West African and Caucasian alleles

• DOI: 10.1016/j.jalz.2014.06.009
• Publication Date: 2014-09-26T02:45:45Z
• Authors: Allen D. Roses; Michael W. Lutz; Ann M. Saunders; Dmitry Goldgaber; Robert Saul; Scott S. Sundseth; P. Anthony Akkari; Stephanie M. Roses; W. Kirby Gottschalk; Keith E. Whitfield; Alexander A. Vostrov; Michael A. Hauser; R. Rand Allingham; Daniel K. Burns; Ornit Chiba‐Falek; Kathleen A. Welsh...
• Keywords: Apolipoprotein E

Abstract Background Several studies have demonstrated a lower apolipoprotein E4 ( APOE ε4) allele frequency in African‐Americans, but yet an increased age‐related prevalence of AD. An algorithm for prevention clinical trials incorporating TOMM40'523 (Translocase Outer Mitochondria Membrane) and depends on accurate TOMM40'523‐ haplotypes. Methods We compared the phased haplotype frequencies 9.5 kb TOMM40/ genomic region West African, Caucasian, African‐American cohorts. Results scans poly‐T lengths connected phase with either ε4 or ε3 differ from both Africans Caucasians represent admixture several distinct African Caucasian A new haplotype, to short allele, is observed African‐Americans not Caucasians. Conclusion These data therapeutic implications age onset risk estimates design trial other mixed ethnic populations.