A 22‐single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42

• DOI: 10.1016/j.jalz.2015.02.013
• Publication Date: 2015-06-15T23:19:35Z
• Authors: Kristel Sleegers; Karolien Bettens; Arne De Roeck; Caroline Van Cauw...; Elise Cuyvers; Jan Verheijen; Hanne Struyfs; Jasper Van Dongen; Steven Vermeulen; Sebastiaan Engelb...; Mathieu Vandenbulcke; Rik Vandenberghe; Peter Paul De Deyn; Christine Van Bro...
• Keywords: SNP; Apolipoprotein E; Genetic predisposition

Abstract Introduction The ability to identify individuals at increased genetic risk for Alzheimer's disease (AD) may streamline biomarker and drug trials aid clinical personal decision making. Methods We evaluated the discriminative of a score (GRS) covering 22 published loci AD in 1162 Flanders‐Belgian patients 1019 controls assessed correlations with family history, onset age, cerebrospinal fluid (CSF) biomarkers (Aβ 1–42 , T‐Tau, P‐Tau 181P ). Results A GRS including all single nucleotide polymorphisms (SNPs) age‐specific APOE ε4 weights reached area under curve (AUC) 0.70, which AUC 0.78 familial predisposition. Risk (odds ratio, 2.32 (95% confidence interval 2.08–2.58 per unit; P < 1.0e −15 Onset age CSF Aβ decreased increasing ( onset_age = 9.0e −11 ; 8.9e −7 Discussion this 22‐SNP is still limited, but these data illustrate that incorporation improves ability. GRS‐phenotype highlight feasibility identifying highest susceptibility.