P4‐215: Quantification of Tau Load Using [18F]AV‐1451 and Pet

• DOI: 10.1016/j.jalz.2016.06.2307
• Publication Date: 2016-10-17T07:38:41Z
• Authors: Tessa Timmers; Sandeep S.V. Golla; Rik Ossenkoppele; Sander C.J. Verfa...; Colin Groot; Philip Scheltens; Wiesje M. van der...; Patrick Schober; Lothar A. Schwarte; Mark A. Mintun; Michael D. Devous; Robert C. Schuit; Albert D. Windhorst; Adriaan A. Lammer...; Ronald Boellaard; Maqsood M. Yaqub; Bart N.M. van Ber...
• Keywords: TRACER; Binding potential; PET Imaging; Standardized uptake value; Tau Pathology

The tau tracer [18F]AV-1451 is a promising ligand for imaging tauopathies such as Alzheimer's disease (AD). Increased uptake of in AD patients compared with healthy controls (HC) has been shown, strong correlation between and cognitive decline. These studies quantified load using the standardized value ratio (SUVr) derived from static scan (80-100 min. post injection). SUVr may, however, be flow dependent and, especially longitudinal studies, should validated against fully quantitative approach. objective this study was to identify optimal kinetic model measuring [18F]AV-1451. Following intravenous injection 228±8 MBq [18F]AV-1451, 130 min dynamic PET scans were performed 3 biomarker confirmed HC. Combined continuous manual arterial blood sampling used obtain metabolite corrected plasma input function. PVELAB Hammers template delineate regions interest (ROIs) on co-registered T1 weighted MRI scan. Next, regional time-activity curves generated by projecting these ROIs onto frames. analyzed reversible non-reversible single two tissue compartment models, both without volume parameter. (1T2k_VB) preferred all For patients, preference shifted towards (2T4k_VB), shown Figure 1, high distribution (VT > 9 mL cm-3). In HC, good (R2 = 1.00, slope 1.01) observed VT 1T2k_VB 2T4k_VB, indicating that 2T4k_VB best group comparisons. 2 shows several (AD specific) ROIs. also suggests cerebellum may reference region AD.