P1‐161: Pro‐Apoptotic Function of Pin1‐Mediated Notch1 Activation in Ischemic Neuronal Death

• DOI: 10.1016/j.jalz.2016.06.908
• Publication Date: 2016-10-17T07:23:17Z
• Authors: Yoonsuk Cho; HarkKyun Kim; Seung Hyun Baek; Jihoon Han; Gun Young Jung; Hee Jin Park; Gahee Bahn; Bo Youn Choi; Dong-Gyu Jo
• Keywords: Knockout mouse; Stroke

The peptidyl-prolyl cis/trans isomerase Pin1 regulates factors involved in control of cell growth and apoptosis. Notch1 is a transmembrane receptor that plays crucial role neurogenesis neuronal death. Overexpression knockdown vitro mice stroke model. increased γ-secretase activity NICD levels, potentiated death ischemia-like condition. By contrast, using siRNA or knockout reduced the level ischemic Also, we found affected by focal ischemia-reperfusion. stimulates activation its pro-apoptotic function following stroke. heterozygote (+/-) (-/-) showed brain damage improved functional outcomes model contributes to pathogenesis promoting Notch signaling.