[DT‐01–02]: THE IMPACT OF AMYLOID PET ON DIAGNOSIS AND PATIENT MANAGEMENT IN AN UNSELECTED MEMORY CLINIC COHORT: THE ABIDE PROJECT

• DOI: 10.1016/j.jalz.2017.08.004
• Publication Date: 2017-10-20T07:32:40Z
• Authors: Arno de Wilde; Wiesje Pelkmans; Femke H. Bouwman; Jurre Verwer; Colin Groot; Marieke van Buchem; Marissa D. Zwan; Rik Ossenkoppele; Maqsood M. Yaqub; Marleen Kunneman; Ellen M. Smets; Frederik Barkhof; Adriaan A. Lammer...; Andrew Stephens; Erik van Lier; Geert Jan Biessels; Bart N.M. van Ber...; Wiesje M. van der...; Philip Scheltens
• Keywords: Etiology; Amyloid (mycology); Memory clinic

Former studies evaluating the diagnostic impact of amyloid PET utilized selected research samples. We performed in an unselected memory cohort and assessed its on diagnosis, confidence diagnosis patient management, taking into account patients’ experiences. As part ABIDE (Alzheimer biomarkers daily practice: EudraCT: 2014–000562–21) project, we offered [18F]florbetaben to all patients visiting our clinic during two years as their routine work-up. For each patient, a pre- post-amyloid was obtained with level varying from 0–100%. Neurologists indicated at both syndromic etiological were required record expected etiology for every even when low. They also recorded management. Patients (n=260) filled out questionnaires asking motivation undergo (before scanning) burden procedure (after scanning). included 502 (mean age:65±8, female:39%, MMSE:25±4) dementia due AD (n=164,33%), other type (n=70,14%), MCI (n=110,22%), SCD (n=158,32%). Amyloid positive 239(48%) (table 1). After PET, changed 123(25%) patients. Diagnostic increased 80%±13 90%±13 (p<0.001). In 131(26%) patients, management after mostly regarding ancillary investigations (e.g. clinical genetics, FDG-PET, consultation psychiatrist) therapy (i.e. offering cholinesterase inhibitors participation trials). Patients’ main reasons receive more certainty (54%), contribute science (48%), or reassurance (14%). Upon completion 19% that they experienced burdensome, mainly duration test claustrophobia, while majority (of 81%) found not burdensome. this contributed change one four appropriate use criteria adopted. addition, MCI. Of note, most reported favorably procedure.