Cortical microstructural changes along the Alzheimer's disease continuum

• DOI: 10.1016/j.jalz.2017.09.013
• Publication Date: 2017-11-01T03:00:19Z
• Authors: Victor Montal; Eduard Vilaplana; Daniel Alcolea; Jordi Pegueroles; Ofer Pasternak; Sofia González‐Ortiz; Jordi Clarimón; María Carmona‐Iragui; Ignacio Illán‐Gala; Estrella Morenas‐...; Roser Ribosa‐Nogué; Isabel Sala; María‐Belén Sánch...; Maite García‐Seba...; Jorge Villanúa; Andrea Izagirre; Ainara Estanga; Mirian Ecay‐Torres; Ane Iriondo; Montserrat Clerigue; Mikel Tainta; Ana Pozueta; Andrea González; Eloy Martínez‐Heras; Sara Llufriu; Rafael Blesa; Pascual Sanchez‐Juan; Pablo Martínez‐Lage; Alberto Lleó; Juan Fortea
• Keywords: Cognitive Decline

Abstract Introduction Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD). Methods We included healthy control subjects (N = 254), mild cognitive impairment 41), AD dementia 31) patients. Participants underwent a lumbar puncture 3 T magnetic resonance imaging. Healthy were classified following National Institute on Aging‐Alzheimer's Association stages (stage 0, N 220; stage 1, 25; 2/3, 9). assessed the cortical MD, FW, thickness (CTh) along continuum. Results Microstructural macrostructural show biphasic trajectory. Stage 1 showed increased CTh decreased MD FW with respect 0 subjects. 2/3 that more widespread in symptomatic stages. Discussion These results support model of AD, which could affect selection patients clinical trials use imaging as surrogate marker modification.