The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology
Frontotemporal lobar degeneration
DOI:
10.1016/j.jalz.2019.06.4947
Publication Date:
2019-10-18T09:34:48Z
AUTHORS (62)
ABSTRACT
Abstract Introduction It is important to establish the natural history of familial frontotemporal lobar degeneration (f‐FTLD) and provide clinical biomarker data for planning these studies, particularly in asymptomatic phase. Methods The Longitudinal Evaluation Familial Frontotemporal Dementia Subjects protocol was designed enroll follow at least 300 subjects more than three annual visits who are members kindreds with a mutation one most common f‐FTLD genes—microtubule‐associated protein tau, progranulin, or chromosome 9 open reading frame 72. Results We present theoretical considerations aims/objectives this protocol. also describe design methodology evaluating rating subjects, which detailed neuropsychological assessments performed, biofluid samples collected, magnetic resonance imaging scans performed using standard Discussion These samples, available interested investigators worldwide, will facilitate upcoming disease‐modifying therapeutic trials f‐FTLD.
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