Melatonin alleviates high temperature exposure induced fetal growth restriction via the gut-placenta-fetus axis in pregnant mice

• DOI: 10.1016/j.jare.2024.02.014
• Publication Date: 2024-02-20T02:56:49Z
• Authors: Jia-Jin Wu; Xiaoyu Zheng; Caichi Wu; Wen Ma; Yibo Wang; Jun Wang; Yulong Wei; Xiangfang Zeng; Shihai Zhang; Wutai Guan; Fang Chen
• Keywords: Fetal growth

Global warming augments the risk of adverse pregnancy outcomes in vulnerable expectant mothers. Pioneering investigations into heat stress (HS) have predominantly centered on its direct impact reproductive functions, while potential roles gut microbiota, despite significant influence distant tissues, remain largely unexplored. Our understanding deleterious mechanisms HS and development effective intervention strategies to mitigate detrimental impacts are still limited.