Chondrocyte deformation during the unloading phase of cyclic compression loading

• DOI: 10.1016/j.jbiomech.2024.112179
• Publication Date: 2024-06-01T00:36:46Z
• Authors: Baaba S. Otoo; Eng Kuan Moo; Amin Komeili; David A. Hart; Walter Herzog

Cell volume and shape changes play a pivotal role in cellular mechanotransduction, governing responses to external loading. Understanding the dynamics of cell behavior under loading conditions is essential elucidate adaptation mechanisms physiological pathological contexts. In this study, we investigated effects dynamic cyclic compression on changes, comparing them with static conditions. Using custom-designed platform which allowed for simultaneous imaging cartilage tissue, tissues were subjected 100 cycles mechanical while measuring alterations during unloading phase at specific time points. The findings revealed transient decrease (13%) early cycles, followed by gradual recovery baseline levels after approximately 20 despite tissue not being fully recovered phase. This observed pattern indicates temporal response that may be associated stimulus through related active regulation. Additionally, study demonstrated significantly distinct from those Such suggest cells their natural environment perceive respond differently compared cues, highlighting significance considering environments studies mechanics. Overall, research contributes broader understanding stimuli, providing valuable insights into ability adapt