Estimation of dermal absorption parameters of cleaning chemical ingredients

• DOI: 10.1016/j.jchas.2018.08.004
• Publication Date: 2018-09-07T04:08:40Z
• Authors: Nishith Ghosh; Pallavee V.K.; J.D. Sharma; A.S. Vajarekar
• Keywords: 03 medical and health sciences; 0302 clinical medicine

Cleaning workers experience occupational hazards, such as skin diseases and respiratory illness, due to their exposure the ingredients of cleaning chemicals. To control chemical through inhalation route, airborne concentration chemicals is maintained within its limits (OELs). However, universally accepted OELs for dermal are lacking. Unavailability experimentally determined values absorption parameters one reasons behind it. Herein, we estimated (e.g., octanol–water partition coefficient, permeability coefficient maximum flux across skin) a number ingredients. Atom/Fragment Contribution (AFC) method was used estimate coefficients. The coefficients were using Potts Guy correlation equation. skin. Estimated these compared that which ACGIH assigned "skin" notation. found similar having fluxes lower than expected help in evaluating hazard