Artificial lipids and macrophage membranes coassembled biomimetic nanovesicles for thoracic aortic dissection treatment

• DOI: 10.1016/j.jconrel.2025.113844
• Publication Date: 2025-05-15T06:38:19Z
• Authors: Yanlin Gao; Li Rong; Jing Cui; Wei Cheng; Lin Fu; Guangpu Fan; Haiyan Wang; Jiaqi Yu; Zhen Li; Dinghong Liu; Sheng Zhao; Houliang Chen; Junchao Qin; Miaomiao Tao; Zhechuan Jin; Yu Chen; Yuyu Li

Thoracic aortic dissection (TAD) is a life-threatening cardiovascular disease characterized by rapid progression and high morbidity. Current efforts to develop effective treatment strategies focus on targeting apoptotic endothelial cells mitigating inflammation. Here, inspired the inflammation-neutralizing capacity of functional cells, we present multifunctional biomimetic nanovesicles (MM-LPs) co-assembled from macrophage membranes synthetic lipids for targeted delivery Senkyunolide I (SEI) in TAD treatment. The integration endows MM-LPs with ability selectively target activated vascular (VECs) while adsorbing proinflammatory cytokines suppress Additionally, these nanoparticles enable controlled release SEI, leading significant anti-apoptotic effects. Leveraging advantages, effectively mitigated VEC activation, reduced apoptosis, prevented rupture BAPN-induced mouse model TAD. Furthermore, this system significantly SEI-associated toxicity adverse effects liver kidneys. These findings highlight potential combining natural drug treating dysfunction minimizing drug-related side