Local field potential journey into the Basal Ganglia

• DOI: 10.1016/j.jdbs.2024.03.002
• Publication Date: 2024-03-26T16:05:48Z
• Authors: Eitan E. Asher; Maya Slovik; Rea Mitelman; Hagai Bergman; Shlomo Havlin; Shay Moshel
• Keywords: Local field potential; Dorsolateral prefrontal cortex

Local field potentials (LFP) in the basal ganglia (BG) have attracted considerable research and clinical interest. The genesis of these signals has been a topic extensive discourse, focusing on whether they are manifestation local synaptic activity or result from propagation electrical through tissue, as described by Maxwell equations (volume conduction). To investigate this, we conducted simultaneous recordings LFPs two cortical areas— dorsolateral prefrontal cortex (DLPFC) primary motor (M1)—and various sites within BG nuclei an awake, non-task-engaged non-human primate (NHP). Employing innovative analytical techniques, discerned significant cross-correlations indicative potential connections, while filtering out non-significant correlations. This allowed us to differentiate between inputs volume conduction. Our findings indicate distinct pathways emanating M1 DLPFC, each characterized different temporal delays. results imply that anatomical differentially influenced mechanisms conduction transmission. Notably, exhibits more functional links with non-zero-time delays structures, DLPFC-BG connections marked zero-time delays, suggesting predominance effects. Consequently, investigations into origins LFP should account for linking BG, represent information flow conductance.