Optimised release of tetracycline hydrochloride from core-sheath fibres produced by pressurised gyration

• DOI: 10.1016/j.jddst.2022.103359
• Publication Date: 2022-05-04T12:06:32Z
• Authors: Hamta Majd; Anthony Harker; Mohan Edirisinghe; Maryam Parhizkar
• Keywords: Tetracycline Hydrochloride; Polycaprolactone

In recent years, there has been a surge of interest in the design, processing, and use core-sheath fibres, especially production wound healing bandages drug delivery. this research, novel pressurised gyration technique was utilised to create antibacterial fibre patches (tetracycline hydrochloride, TEHCL) using polyvinyl pyrrolidone (PVP) polycaprolactone (PCL). Antibiotic showed uniform fibres with porous surface giving rise biphasic delivery system, which provided an initial burst 30–48% release first 24 h followed by constant rate throughout course 168 h, suitable for wound-dressings application. The effect operating parameters on morphology, influence structure loading as well mathematical modelling investigated analysed. Fourier-transform infrared spectroscopy, differential scanning calorimetry results demonstrated successful TEHCL encapsulation presence both polymers fibres. morphology studied electron microscopy verified confocal microscopy. Therefore, method offers exciting chance customise hybrid polymeric system. These advancements are crucial world healthcare meet demands where dressings cannot be produced rapidly or when personalised approach is necessary.