Fragrant rapeseed oil consumption prevents blood cholesterol accumulation via promoting fecal bile excretion and reducing oxidative stress in high cholesterol diet fed rats

• DOI: 10.1016/j.jff.2021.104893
• Publication Date: 2021-12-09T18:57:52Z
• Authors: Xue Tang; Yingying Zheng; Tristan C. Liu; Jianguo Liu; Jun Wang; Yipin Lu; Kai Zhang; Peng Zhou
• Keywords: Antioxidant status; 2. Zero hunger; 0303 health sciences; 03 medical and health sciences; Refining; Nutrition. Foods and food supply; Cholesterol metabolism; Rapeseed oil; TX341-641; Roasting temperature

We investigated the compositional changes and effects of long-term supplementation on blood lipids in three rapeseed oils [refined (RO), roasted at 120 °C (FO-120) 150 (FO-150)]. Sixty Sprague-Dawley rats were fed either a basal diet or one five high-cholesterol diets comprising lard, lard with cholestyramine, for 12 weeks. Results showed that FO-120 FO-150 alleviated plasma total cholesterol increased fecal bile acid excretion, but RO had no significant effect. In liver, synthesis conversion mRNA expression altered by feeding, like inhibition Hmgcr activation Cyp7a1. Furthermore, hepatic eicosapentaenoic docosahexaenoic production favorably improved redox status. Overall, hypocholesterolemic may be attributed to their high levels α-linolenic polyphenols, linked closely regulating metabolism, promoting highly-unsaturated fatty acids synthesis, reducing oxidative stress.