C-phycocyanin extracted from Spirulina using a green solvent approach presents an anti-obesity characteristic in mice fed a hyperlipidic diet

• DOI: 10.1016/j.jff.2023.105747
• Publication Date: 2023-08-26T03:12:21Z
• Authors: A.F. Silva-Neto; C. Fratelli; V.G. Pucci; V.T. Boldarine; Y.A.M. Ferreira; M.M. Telles; A.R.C. Braga; L.M. Oyama
• Keywords: Resistin; Spirulina (dietary supplement)

The effects of C-phycocyanin extract, obtained from Spirulina biomass using a sustainable method with water as solvent, on the white adipose tissue male mice fed high-fat diet were evaluated. normolipid and groups similar regarding body mass gain, leptin concentration phosphorylated protein nuclear factor kappa B p-50 subunit expression. group showed notable reduction in serum resistin (88.18 ± 31.54, 158.5 52.43) (pg/mL) pro-inflammatory cytokine tumor necrosis alpha (p < 0.05) 16 weeks treatment within retroperitoneal tissue. has been associated obesity development, utilization artificial dyes linked to adverse effects. However, C-phycocyanin, natural pigment, demonstrated promising outcomes. Our findings suggest that extract effectively inhibited regulated levels, prevented increase state.