Epidemiological and genomic features of clinical isolates of the Elizabethkingia genus in Taizhou City, China

• DOI: 10.1016/j.jgar.2025.04.017
• Publication Date: 2025-04-26T22:35:38Z
• Authors: Yingying Cai; Qingxin Shi; Sufei Yu; Haohao Li; Yang Yang; Donglian Wang; Tao-Hsin Tung; Bo Shen; Mengyuan Chen

Elizabethkingia species usually exhibit resistance to multiple antibiotics, and inappropriate antimicrobial therapy is a major cause of mortality in patients with infection. Our study aimed comprehensively analyze compare the genomic clinical features three species. Matrix-assisted laser desorption/ionization-time flight mass spectrometry whole-genome sequencing were used identify 88 isolates from past 6 years. Phylogenetic tree Sankey diagram analysis strains metallo-β-lactamase genes 49 miricola evolutionary relationships. The identified included anophelis (65/88,73.9%), meningoseptica (8/88, 9.1%), (15/88, 17.0%). Multivariate showed that co-isolated Pseudomonas aeruginosa (odds ratio: 40.83, 95% confidence interval: 3.05-546.29, p = 0.005) exposure carbapenems 5.76, 1.00-248.32, 0.050) independent risk factors for in-hospital mortality. Whole-genome phylogenetic revealed all 22 BlaBlaB 19 BlaGOB variants. In particular, specific combinations BlaB GOB subtypes differed All harbored drug-resistance adeF, vanT, vanW shared 32 virulence-associated genes. Global evolution E. dispersal Chinese did not display outbreak possibility. Variations virulence are associated natural pathogenicity Elizabethkingia. Increased monitoring recommended deeper understanding pathogenic mechanisms spp.