Metronomic cyclophosphamide: An alternative treatment for hepatic epithelioid hemangioendothelioma

• DOI: 10.1016/j.jhep.2013.01.043
• Publication Date: 2013-02-09T00:48:04Z
• Authors: Zaher Lakkis; Stefano Kim; Eric Delabrousse; Marine Jary; Thierry Nguyen; Georges Mantion; Bruno Heyd; Catherine Lassabe; Christophe Borg
• Keywords: Epithelioid Hemangioendothelioma; Hemangioendothelioma

Hepatic epithelioid hemangioendothelioma is a rare liver mesenchymatous tumor with an epithelial aspect developed from endothelial cells lack of validated therapeutic options at metastatic stage. Metronomic chemotherapy has been described as anti-angiogenic therapy leading to the depletion circulating progenitors. We report results two patients treated for metronomic cyclophosphamide chemotherapy. Following initiation (50mg once day continuously), exhibited significant clinical improvement and decrease in metastasis size without any clinically relevant side-effect. could be proposed new option treat hepatic hemangioendothelioma.