Validation of Baveno VII criteria for recompensation in entecavir-treated patients with hepatitis B-related decompensated cirrhosis

• DOI: 10.1016/j.jhep.2022.07.037
• Publication Date: 2022-08-28T05:23:07Z
• Authors: Qi Wang; Hong Zhao; You Deng; Huanwei Zheng; Huiling Xiang; Yuemin Nan; Jinhua Hu; Qinghua Meng; Xiaoyuan Xu; Jilian Fang; Jie Xu; Xiaoming Wang; Hong You; Calvin Q. Pan; Wen Xie; Jidong Jia
• Keywords: Entecavir; Liver function; Hepatic Encephalopathy; Liver disease; Hepatitis B

•This is the first prospective validation of Baveno VII recompensation definition in patients with HBV-related cirrhosis.•A stable improvement liver function tests was defined as MELD <10 and/or ALB & INR TBIL within Child-Pugh A.•On-treatment scores may be more predictive probability than baseline scores.•Prompt antiviral therapy effective for cirrhosis, even under severe conditions. Background AimsAntiviral improves clinical outcomes chronic hepatitis B (CHB), including those cirrhosis. In present study, we validated and explored criteria entecavir-treated CHB-related decompensated cirrhosis.MethodsIn this multicentre (ascites) cirrhosis were enrolled treated entecavir 120 weeks. Patients followed up events, viral biochemical tests, ultrasonography every 6 months. The rate per calculated. Multivariate regression models used to identify predictors recompensation. Finally, explored.ResultsOf 320 recruited patients, 283 completed 120-week 261/283 (92.2%) achieving HBV DNA levels <20 IU/ml 171/283 (60.4%) resolution ascites, encephalopathy, absence recurrent variceal bleeding at least 12 We identified model end-stage disease Class A (albumin >35 g/L, international normalised ratio <1.50 total bilirubin <34 μmol/L) tests. Accordingly, 56.2% (159/283) fulfilled a by current study.ConclusionsOur study required on therapy. derived from warrant further other aetiologies.Lay summaryDecompensation marks point which no longer able normally (and symptoms become apparent). Recently idea proposed individuals who experience an if underlying cause their addressed (e.g. antivirals cirrhosis). Herein, show that over 50% B-related could recompensate propose laboratory define Antiviral explored. Of study. Our aetiologies.