Baveno VII algorithm outperformed other models in ruling out high-risk varices in individuals with HBV-related cirrhosis

• DOI: 10.1016/j.jhep.2022.10.030
• Publication Date: 2022-11-07T16:57:55Z
• Authors: Xiaofeng Zhang; Jiankang Song; Yuanjian Zhang; Biao Wen; Lin Dai; Ranran Xi; Qiaoping Wu; Yuan Li; Xiaoqin Luo; Xiaoqin Lan; Qinjun He; Wenfan Luo; Qintao Lai; Yali Ji; Ling Zhou; Tingting Qi; Miaoxia Liu; Fuyuan Zhou; Weiqun Wen; Hui Li; Zhihua Liu; Yongpeng Chen; Youfu Zhu; Junying Li; Jing Huang; Xiao Cheng; Minghan Tu; Jinlin Hou; Haiyu Wang; Jinjun Chen
• Keywords: Esophagogastroduodenoscopy

Highlights•We validated the excellent performance of Baveno VII algorithm for ruling out HRV in those with HBV-related cirrhosis.•Compared VI, LSPS, PSR and RESIST, performed best avoiding unnecessary EGDs.•When applying cirrhosis, SSM@100 Hz probe better than SSM@50 Hz.AbstractBackground & AimsThe consensus recommends that spleen stiffness measurement (SSM) ≤40 kPa is safe high-risk varices (HRVs) endoscopic screening patients who do not meet VI criteria. This study aimed to validate individuals cirrhosis.MethodsConsecutive cirrhosis underwent liver (LSM) SSM – using a 50 shear wave frequency, diameter measurement, esophagogastroduodenoscopy (EGD) were prospectively enrolled from June 2020. A 100 has been adopted additional assessment since July 2021.ResultsFrom 2020 January 2022, 996 screened 504 analysis. Among whom was assessed probe, avoided more EGDs (56.7% vs. 39.1%, p <0.001) criteria, comparable missed rate (3.8% 2.5%). Missed rates >5% all other measures: 11.3% LSM-longitudinal platelet ratio score, 20.0% count/longitudinal ratio, 8.8% Rete Sicilia Selezione Terapia-hepatitis. 232 patients, spared (75.4% 59.5%, Hz, both 3.0% (1/33).ConclusionsWe algorithm, demonstrating cirrhosis. Furthermore, could safely rule Hz.Clinical trial numberNCT04890730.Impact implicationsThe guideline proposed avoid further screening. The current probes, which exhibited HRVs Compared had capability EGDs. will be practical tool triage future clinical practice.Graphical abstract