Rare HCV subtypes and retreatment outcomes in a cohort of European DAA-experienced patients

• DOI: 10.1016/j.jhepr.2024.101072
• Publication Date: 2024-03-25T17:50:15Z
• Authors: Julia Dietz; Christiana Graf; Christoph P. Berg; Kerstin Port; Katja Deterding; Peter Buggisch; Kai-Henrik Peiffer; Johannes Vermehren; Georg Dultz; Andreas Geier; Florian P. Reiter; Tony Bruns; Jörn M. Schattenberg; Elena Durmashkina; Thierry Gustot; Christophe Moreno; Janina Trauth; Thomas Discher; Janett Fischer; Thomas Berg; Andreas E. Kremer; Beat Müllhaupt; Stefan Zeuzem; Christoph Sarrazin; C. Antoni; A. Teufel; R. Vogelmann; M. Ebert; J. Balavoine; E. Giostra; M. Berning; J. Hampe; T. Boettler; C. Neumann-Haefelin; R. Thimme; A. De Gottardi; A. Rauch; N. Semmo; V. Ellenrieder; M. Gress; A. Herrmann; A. Stallmach; D. Hoffmann; U. Protzer; A. Kodal; M. Löbermann; T. Götze; V. Keitel-Anselmino; C.M. Lange; R. Zachoval; J. Mayerle; A. Maieron; P. Michl; U. Merle; D. Moradpour; J.-P. Chave; M. Muche; H.-J. Epple; M. Müller-Schilling; F. Kocheise; T. Müller; F. Tacke; E. Roeb; J. Rissland; M. Krawczyk; P. Schulze; D. Semela; U. Spengler; J. Rockstroh; C.P. Strassburg; J. Siebler; J. Schulze zur Wi...; F. Piecha; J. von Felden; S. Jordan; A. Lohse; M. Sprinzl; P. Galle; R. Stauber; B. Strey; W. Steckstor; W. Schmiegel; N.H. Brockmeyer; A. Canbay; C. Trautwein; F. Uschner; J. Trebicka; T. Weber; H. Wedemeyer; M. Cornberg; M. Manns; P. Wietzke-Braun; R. Günther; K. Willuweit; G. Hilgard; H. Schmidt; E. Zizer; J. Backhus; T. Seufferlein; O. Al-Taie; W. Angeli; S. Beckebaum; A. Erhardt; A. Garrido-Lüneburg; H. Gattringer; D. Genné; M. Gschwantler; F. Gundling; S. Hametner; R. Schöfl; S. Haag; H. Heinzow; T. Heyer; C. Hirschi; A. Jussios; S. Kanzler; N. Kordecki; M. Kraus; U. Kullig; S. Wollschläger; L. Magenta; B. Terziroli Bere...; M. Menges; L. Mohr; K. Muehlenberg; C. Niederau; B. Paulweber; A. Petrides; M. Pinkernell; R. Piso; W. Rambach; L. Reinhardt; M. Reiser; B. Riecken; A. Rieke; J. Roth; M. Schelling; P. Schlee; A. Schneider; D. Scholz; E. Schott; M. Schuchmann; U. Schulten-Baumer; A. Seelhoff; A. Stich; F. Stickel; J. Ungemach; E. Walter; A. Weber; H. Wege; T. Winzer; W. Abels; M. Adler; F. Audebert; C. Baermann; E. Bästlein; R. Barth; K. Barthel; W. Becker; J. Behrends; J. Benninger; F. Berger; D. Berzow; T. Beyer; M. Bierbaum; O. Blaukat; A. Bodtländer; G. Böhm; N. Börner; U. Bohr; B. Bokemeyer; H.R. Bruch; D. Bucholz; P. Buggisch; K. Matschenz; J. Petersen; O. Burkhard; N. Busch; C. Chirca; R. Delker; J. Diedrich; M. Frank; M. Diehl; A.O. Tal; M. Schneider; A. Dienethal; P. Dietel; N. Dikopoulos; M. Dreck; F. Dreher; L. Drude; K. Ende; U. Ehrle; K. Baumgartl; F. Emke; R. Glosemeyer; G. Felten; D. Hüppe; J. Fischer; U. Fischer; D. Frederking; B. Frick; G. Friese; B. Gantke; P. Geyer; H.R. Schwind; M. Glas; T. Glaunsinger; F. Goebel; U. Göbel; B. Görlitz; R. Graf; H. Gruber; C. Hartmann; C. Klag; G. Härter; M. Herder; T. Heuchel; S. Heuer; H. Hinrichsen; B. Seegers; K.-H. Höffl; H. Hörster; J.-U. Sonne; W.P. Hofmann; F. Holst; M. Hunstiger; A. Hurst; E. Jägel-Guedes; C. John; M. Jung; B. Kallinowski; B. Kapzan; W. Kerzel; P. Khaykin; M. Klarhof; U. Klüppelberg; Wolfratshausen; K. Klugewitz; B. Knapp; U. Knevels; T. Kochsiek; A. Körfer; A. Köster; M. Kuhn; A. Langekamp; B. Künzig; R. Link; M. Littman; H. Löhr; T. Lutz; P. Gute; G. Knecht; U. Lutz; D. Mainz; I. Mahle; P. Maurer; S. Mauss; C. Mayer; H. Möller; R. Heyne; D. Moritzen; M. Mroß; M. Mundlos; U. Naumann; O. Nehls; K; R. Ningel; A. Oelmann; H. Olejnik; K. Gadow; E. Pascher; A. Philipp; M. Pichler; F. Polzien; R. Raddant; M. Riedel; S. Rietzler; M. Rössle; W. Rufle; A. Rump; C. Schewe; C. Hoffmann; D. Schleehauf; W. Schmidt; G. Schmidt-Heinev...; J. Schmidtler-von...; L. Schneider; A. Schober; S. Niehaus-Hahn; J. Schwenzer; B. Seegers; T. Seidel; G. Seitel; C. Sick; K. Simon; D. Stähler; F. Stenschke; H. Steffens; K. Stein; M. Steinmüller; T. Sternfeld; B. Strey; K. Svensson; W. Tacke; G. Teuber; K. Teubner; J. Thieringer; A. Tomesch; U. Trappe; J. Ullrich; G. Urban; S. Usadel; A. von Lucadou; F. Weinberger; M. Werheid-Dobers; P. Werner; T. Winter; E. Zehnter; A. Zipf
• Keywords: 0301 basic medicine; Hepatitis C Virus; 0303 health sciences; treatment response; 610; rare HCV genotypes; resistance-associated substitutions; RC799-869; Diseases of the digestive system. Gastroenterology; Direct-acting antivirals; Research Article

BackgroundData on the prevalence and characteristics of so called rare HCV genotypes (GT) in larger cohorts is limited. This study investigates frequency GT resistance-associated substitutions efficacy retreatment a European cohort.MethodsA total 129 patients with GT1-6 were included from resistance database. NS3, NS5A NS5B sequenced clinical parameters efficacies collected retrospectively.ResultsOverall 1.5% (69/4656) DAA-naïve 4.4% (60/1376) DAA-failure infected GT. While almost equally distributed throughout patients, we detected mainly GT4 (47%, 28/60 GT4; these n=17, subtype 4r) GT3 (25%, 15/60 GT3, n=8, 3b) among DAA-failures. 62% (37/60) DAA failures had not responded to first-generation regimes majority was (57%, 21/37). In contrast, failure pangenotypic regimens (38%, 23/60), infections overrepresented 13/23). RASs uncommon GT2, GT5a GT6, observed combined GT1, at positions 28, 30, 31, which can be considered as inherent. completed follow-up retreatment, achieved high SVR rate (94%, 45/48 mITT; 92%, 45/49 ITT). Three GT4f, 4r or 3b, respectively, virological treatment failure.ConclusionsIn this cohort, uncommon. Accumulation specific suggests reduced antiviral activities regimens. The limited global availability for first line therapy well multiple targeted could result elimination targets being delayed.Impact implicationsData are still scarce. found low rates HCV-infected patients. subtypes accumulated after 1st generation viral 30 31. delayed.