Clinical characteristics and outcomes of hematogenous vertebral osteomyelitis caused by gram-negative bacteria

• DOI: 10.1016/j.jinf.2014.02.009
• Publication Date: 2014-02-21T02:46:00Z
• Authors: Ki-Ho Park; Oh Hyun Cho; Myounghwa Jung; Kyung-Soo Suk; Jung Hee Lee; Ji Seon Park; Kyung Nam Ryu; Sung-Han Kim; Sang-Oh Lee; Sang-Ho Choi; In-Gyu Bae; Yang Soo Kim; Jun Hee Woo; Mi Suk Lee
• Keywords: Antibiotic Therapy

To evaluate the clinical characteristics and outcomes of patients with hematogenous vertebral osteomyelitis (HVO) caused by gram-negative bacteria (GNB).We conducted a retrospective chart review of adult patients with HVO from three tertiary-care hospitals over a 7-year period.Of the 313 microbiologically diagnosed HVO cases, GNB was responsible for 65 (20.8%) cases. Compared with patients with MSSA HVO, patients with GNB HVO were more likely to be female (P = 0.03) and have diabetes (P = 0.03), but less likely to have epidural abscess (P = 0.02) and paravertebral abscess (P = 0.003). Clinical outcomes were similar between the GNB and MSSA groups, including in-hospital mortality (4.6% vs. 7.8%; P = 0.53), recurrence (9.7% vs. 4.3%; P = 0.20), and sequelae (31.7% vs. 32.2%; P = 0.95). Among GNB-infected patients, recurrence rates differed according to the total duration of antibiotic treatment: 40.0% (4-6 weeks), 33.3% (6-8 weeks), and 2.1% (≥ 8 weeks) (P = 0.002).GNB HVO was responsible for 20.8% of adult cases of HVO. Despite some differences in clinical and radiological presentation, clinical outcomes were similar between GNB and MSSA HVO. Antibiotic therapy for ≥ 8 weeks may benefit patients with GNB HVO.