Broad spectrum antimicrobial activity of dispirooxindolopyrrolidine fused acenaphthenone heterocyclic hybrid against healthcare associated microbial pathogens (HAMPs)

• DOI: 10.1016/j.jiph.2020.09.016
• Publication Date: 2020-10-24T21:25:32Z
• Authors: Abdulrahman I. Al...; Natarajan Arumugam; Raju Suresh Kumar; Rajesh Raju; Karuppiah Ponmurugan; NaifAbdullah AlDhabi; Dhanaraj Premnath
• Keywords: Broad spectrum

Healthcare-associated infections (HAI) are prime health task worldwide and issue of patient safety besides intensifying antimicrobial drug resistance. It is essential to formulate structurally fascinating novel, active cost-effective anti-microbial drugs possessing a peculiar way action capable overcoming the resistance effectively combat this disease. The synthesized spiro-heterocyclic hybrids (SHHs) were elucidated through spectroscopic analysis assessed for their in vitro activity by agar diffusion method minimal inhibitory concentration (MIC) value was also determined. In addition, antioxidant potential evaluated DPPH radical scavenging assays. novel class SHHs 4a 4b displayed significant antibacterial against selected healthcare associated microbial pathogens (HAMPs). SHH showed potent properties. Antibacterial antifungal dispirooxindolopyrrolidine fused acenaphthenone heterocyclic examined. Interestingly, exhibited HAMPs. Further, these compounds These results revealed that promising lead development new drugs.