In-vitro assessment of first-line antifungal drugs against Aspergillus spp. caused human keratomycoses

• DOI: 10.1016/j.jiph.2020.10.014
• Publication Date: 2020-11-06T03:50:34Z
• Authors: Anamangadan Shafe...; Annanthode Balakr...; Coimbatore Subram...; Arumugam Mythili; Sreeram Suresh; Baskaran Abirami; Raed Abdullah Alh...; Saleh Abdullah Al...; Ahmed Abdel-hadi; Mohamed F. Awad; Randa Mohamed Ismail; Kanesan Panneer S...; Palanisamy Manika...
• Keywords: Natamycin; Clotrimazole; Econazole; Fungal Keratitis; Aspergillus terreus; Aspergillus niger

Aspergillus keratitis are in the increasing trend and reported as second most common cause of mycotic developing countries. The present study was designed to isolate, identify spp. from keratits/corneal ulcer patients attending a tertiary care eye hospital, Coimbatore, South India assess minimum inhibitory concentrations (MICs) against ten clinically used first-line antifungal drugs. A total seventy-three strains isolated corneal scrapings were included assessed for period one year. All isolates identified up species level by morphological observations. Antifungal drug susceptibilities determined standard panel agents. Five different aspergilli, A. flavus (n=53), fumigatus (n=14), terreus (n=9), tamarii (n=6) niger (n=3) based on features. Minimum concentration analyses indicated that, voriconazole, natamycin, itraconazole, clotrimazole, econazole followed ketoconazole shall be order choices effective treatment keratitis.