Synergistic anti-bacterial effects of green synthesized zinc oxide nanoparticles with levofloxacin

• DOI: 10.1016/j.jksus.2023.102905
• Publication Date: 2023-09-16T02:30:34Z
• Authors: Falak Thakral; Hardeep Singh Tuli; Saurabh Gupta; Hemant Joshi; Sami S. Ashgar; Hani Faidah; Farkad Bantun; Petr Slama; Shafiul Haque
• Keywords: Enterococcus faecalis; Agar diffusion test; Silver nanoparticle; Bacterial growth

Nowadays, the emergence of drug resistance was a major problem due to limited bioavailability and unintended toxicity antibiotics because non-specific targeting leading difficulty eradicate pathogenic infections. Zinc oxide nanoparticles gain much attention as nanocarriers, their non-toxic, eco-friendly, economical cost, treat severe The purpose this research produce analyze zinc (ZnONPs) functions using green synthesis process evaluate its anti-bacterial biofilm inhibitory activities against gram-positive -negative microorganisms. ZnONPs were formed via synthetic approach seed extract soybean (Glycine max) characterization done FESEM, X-ray diffraction, UV-VIS spectroscopy, EDAX. ZnONPs, levofloxacin, levofloxacin-loaded determined agar disc diffusion assay microtiter plate assay, respectively. Levofloaxcin-loaded showed more potent statistically significant antibacterial activity than alone Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis. bacterial inhibition zone at 80 µg/ml concentrations higher in comparison standard levofloxacin which possess effective that prevent growth diverse Our findings revealed have an wide range antimicrobial effects could be used for eradication