Evaluation on the corrosion resistance, antibacterial property and osteogenic activity of biodegradable Mg-Ca and Mg-Ca-Zn-Ag alloys

• DOI: 10.1016/j.jma.2021.05.013
• Publication Date: 2021-06-16T17:47:52Z
• Authors: Hewei Chen; Bo Yuan; Rui Zhao; Xiao Yang; Zhanwen Xiao; Antoniac Aurora; Bita Ana Iulia; Xiangdong Zhu; Antoniac Vasile I...; Xingdong Zhang
• Keywords: Biocompatibility; Degradation

The rapid degradation of magnesium (Mg)-based implants in physiological environment limits its clinical applications, and alloying treatment is an effective way to regulate the rate Mg-based materials. In present study, three Mg alloys, including Mg-0.8Ca (denoted as ZQ), Mg-0.8Ca-5Zn-1.5Ag ZQ71) Mg-0.8Ca-5Zn-2.5Ag ZQ63), were fabricated by with calcium (Ca), zinc (Zn) silver (Ag). results obtained from electrochemical corrosion tests vitro evaluation demonstrated that alloys exhibited distinct resistance, ZQ71 lowest among them. After addition Zn Ag, antibacterial potential was also enhanced. cell experiments showed all had good biocompatibility. implantation a rat femoral defect, significantly higher osteogenic activity bone substitution than ZQ63 ZQ, due resistance well stimulatory effects released metallic ions. addition, average daily each alloy vivo vitro, could be site located highly vascularized trabecular region. Importantly, correlations between parameters systematically analyzed find out predictors performance current work not only evaluated biodegradable grafts but provided feasible approach for predicting behavior