A novel Mg-Zn-Nd-Zr alloy lumbar interbody fusion cage: An in vitro and in vivo study

• DOI: 10.1016/j.jma.2024.06.017
• Publication Date: 2024-06-25T11:45:51Z
• Authors: Pengfei Chi; Wen Yu; Bing Wu; Ming Gao; Kai Song; Kaige Mao; Bo Li; Xuanhui Liu; Haoming Liu; Chuyue Zhang; Jianheng Liu; Yang Yu; Qiaoling Chen; Ruoxin Zhao; Ning Yu; Keya Mao; Ke Yang; Lili Tan; Yan Wang; Zheng Wang
• Keywords: Cage; Biocompatibility

Interbody fusion is recognized as the golden standard of surgical intervention for degenerative disc disease (DDD). cage made polyetheretherketone (PEEK) commonly used in lumbar interbody surgery treatment DDD worldwide. However, there are some limitations PEEK including their bio-inert nature and impediment to host bone integration. This study aimed evaluate degradation profile osteoinductive potential biodegradable Mg-Zn-Nd-Zr cages with/without micro-arc oxidation (MAO) coatings. The alloy cages, whether coated with MAO or not, demonstrated commendable biocompatibility biomechanical properties. Immersion electrochemical tests show better corrosion resistance coatings vitro. mRNA sequencing, RT-qPCR Western blotting revealed that Mg-Zn-Nd-Zr/MAO had a effectiveness on osteoinductivity. In vivo evaluations ovine models over 12 weeks 24 post-implantation radiological histological evidence enhanced formation adjacent compared counterparts. Moreover, MAO-coated exhibited reduced propensity gas formation. superior material PEEK, coating offering an advantage mitigating production. Nonetheless, further research warranted refine alloy's composition surface treatments, particularly address challenges associated rapid evolution during early period.