Facile synthesis of manganese ferrite/graphene oxide nanocomposites for controlled targeted drug delivery

• DOI: 10.1016/j.jmmm.2015.10.096
• Publication Date: 2015-10-27T13:47:22Z
• Authors: Guangshuo Wang; Yingying Ma; Lina Zhang; Jingbo Mu; Zhixiao Zhang; Xiaoliang Zhang; Hongwei Che; Yongmei Bai; Junxian Hou
• Keywords: Superparamagnetism; Nanocarriers; Targeted drug delivery

Abstract In this study, manganese ferrite/graphene oxide (MnFe 2 O 4 /GO) nanocomposites as controlled targeted drug delivery were prepared by a facile sonochemical method. It was found that GO nanosheets were fully exfoliated and decorated with MnFe 2 O 4 nanoparticles having diameters of 5–13 nm. The field-dependent magnetization curve indicated superparamagnetic behavior of the obtained MnFe 2 O 4 /GO with saturation magnetization of 34.9 emu/g at room temperature. The in vitro cytotoxicity testing exhibited negligible cytotoxicity of as-prepared MnFe 2 O 4 /GO even at the concentration as high as 150 μg/mL. Doxorubicin hydrochloride (DOX) as an anti-tumor model drug was utilized to explore the application potential of MnFe 2 O 4 /GO for controlled drug delivery. The drug loading capacity of this nanocarrier was as high as 0.97 mg/mg and the drug release behavior showed a sustained and pH-responsive way.