Quantitative high-resolution on-line NMR spectroscopy in reaction and process monitoring

• DOI: 10.1016/j.jmr.2003.09.003
• Publication Date: 2003-11-20T13:03:07Z
• Authors: Michael Maiwald; Holger H Fischer; Young-Kyu Kim; Klaus Albert; Hans Hasse
• Keywords: 7. Clean energy; 01 natural sciences; 0104 chemical sciences

On-line nuclear magnetic resonance spectroscopy (on-line NMR) is a powerful technique for reaction and process monitoring. Different set-ups for direct coupling of reaction and separation equipment with on-line NMR spectroscopy are described. NMR spectroscopy can be used to obtain both qualitative and quantitative information from complex reacting multicomponent mixtures for equilibrium or reaction kinetic studies. Commercial NMR probes can be used at pressures up to 35 MPa and temperatures up to 400 K. Applications are presented for studies of equilibria and kinetics of complex formaldehyde-containing mixtures as well as homogeneously and heterogeneously catalyzed esterification kinetics. Direct coupling of a thin-film evaporator is described as an example for the benefits of on-line NMR spectroscopy in process monitoring.