Magnetic resonance microscopy of biofilm structure and impact on transport in a capillary bioreactor

• DOI: 10.1016/j.jmr.2004.01.009
• Publication Date: 2004-02-07T10:16:00Z
• Authors: Joseph D Seymour; Sarah L Codd; Erica L Gjersing; Philip S Stewart
• Keywords: 0301 basic medicine; Microscopy; Magnetic Resonance Spectroscopy; Biological Transport, Active; Water; Image Enhancement; Magnetic Resonance Imaging; 03 medical and health sciences; Bioreactors; Biofilms; Staphylococcus epidermidis; Rheology; Capillary Action

Microorganisms that colonize surfaces, biofilms, are of significant importance due to their role in medical infections, subsurface contaminant remediation, and industrial processing. Spatially resolved data on the distribution of biomass within a capillary bioreactor, the heterogeneity of the biofilm itself and the impact on transport dynamics for a Staphylococcus epidermidis biofilm in the natural growth state are presented. The data demonstrate the ability of magnetic resonance microscopy to study spatially resolved processes in bacterial biofilms, thus providing a basis for future studies of spatially resolved metabolism and in vivo clinical detection.