Decoupled LIGHT-SABRE variants allow hyperpolarization of asymmetric SABRE systems at an arbitrary field

• DOI: 10.1016/j.jmr.2019.106577
• Publication Date: 2019-08-17T11:09:48Z
• Authors: Jacob R. Lindale; Christian P.N. Ta...; Shannon L. Eriksson; Warren S. Warren
• Keywords: Electromagnetic Fields; Light; Ligands; Nuclear Magnetic Resonance, Biomolecular; 01 natural sciences; Algorithms; Catalysis; Hydrogen; 0104 chemical sciences

Signal Amplification By Reversible Exchange, or SABRE, uses the singlet-order of parahydrogen to generate hyperpolarized signals on target nuclei, bypassing the limitations of traditional magnetic resonance. Experiments performed directly in the magnet provide a route to generate large magnetizations continuously without having to field-cycle the sample. For heteronuclear SABRE, these high-field methods have been restricted to the few SABRE complexes that exhibit efficient exchange with symmetric ligand environments as co-ligands induce chemical shift differences between the parahydrogen-derived hydrides, destroying the hyperpolarized spin order. Through careful consideration of the underlying spin physics, we introduce 1H decoupled LIGHT-SABRE pulse sequence variants which bypasses this limitation, drastically expanding the scope of heteronuclear SABRE at high field.